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Can anyone help me to identify the problem, pest or disease. I have been treating it with Neem oil and bicarbonate but no improvement?

Treating when you do not know what the problem is is not a good idea. We need a lot more information, how have you been watering, where are you? Where has it been sited in your garden? I think it could have been caused by a lack of water at some time.

There are 2 variations of cotoneaster, one of which retains its leaves in winter, the other loses its leaves. It is important to know if the shrub was deciduous in the past. Then the discoloration may indicate that the shrub is going dormant and not some pest or disease.